Related Experiment Videos
Heparin clearance profiles after systemic anticoagulation using a heparin removal device system
W Tao1, J D Callahan, R A Vertrees
1Department of Surgery, University of Texas Medical Branch, Galveston 77555-0528, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|December 5, 1997
Summary
A novel heparin removal device system (HRDS) effectively clears heparin using plasma separation and affinity adsorption. Increasing HRDS blood flow significantly reduces heparin levels, improving patient safety during procedures like cardiopulmonary bypass.
Area of Science:
- Biomedical Engineering
- Cardiovascular Surgery
- Pharmacology
Background:
- Protamine administration for heparin reversal carries risks of adverse reactions.
- Extracorporeal heparin removal is crucial in procedures like cardiopulmonary bypass.
- Existing heparin reversal methods have limitations.
Purpose of the Study:
- To develop and characterize an extracorporeal heparin removal device system (HRDS).
- To establish a mathematical model for predicting heparin removal efficiency.
- To validate the HRDS performance in a preclinical model.
Main Methods:
- Developed an HRDS utilizing plasma separation and affinity adsorption.
- Characterized heparin clearance kinetics as first-order exponential depletion.
- Validated the HRDS in a swine model undergoing hypothermic cardiopulmonary bypass.
Main Results:
- A mathematical model accurately predicted heparin removal time based on HRDS flow and body weight.
- Higher HRDS flow (1400 ml/min) significantly reduced heparin levels compared to lower flow (700 ml/min).
- The HRDS demonstrated effective heparin clearance, with predicted and actual results closely matching.
Conclusions:
- Heparin clearance by the HRDS can be precisely predicted using a first-order exponential depletion model.
- Increasing HRDS flow is an effective strategy to expedite heparin removal.
- The HRDS shows promise for reducing heparin-related risks in clinical practice.