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Oxygen radicals and renal diseases
1Department of Internal Medicine, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, Mo. 63110, USA. sklahr@imgate.wustl.edu
Mineral and Electrolyte Metabolism
|January 1, 1997
Summary
Reactive oxygen metabolites cause kidney damage in acute renal failure and other kidney diseases. Antioxidants may help mitigate this damage by scavenging these harmful oxygen radicals.
Area of Science:
- Nephrology
- Biochemistry
- Molecular Biology
Background:
- Reactive oxygen metabolites (ROMs) are implicated in renal damage.
- Specific ROMs include superoxide, hydrogen peroxide, hydroxyl radical, and hypochlorous acid.
- These compounds play a role in acute renal failure and glomerular/tubulointerstitial diseases.
Purpose of the Study:
- To discuss the role of ROMs in renal damage.
- To consider the effects of antioxidants and radical scavengers.
- To explore the role of oxygen radicals in gene transcription regulation.
Main Methods:
- Literature review and discussion of existing research.
- Analysis of the mechanisms of renal damage by ROMs.
- Evaluation of therapeutic strategies involving antioxidants.
Main Results:
- ROMs are significant mediators of renal injury in various kidney conditions.
- Antioxidants and radical scavengers show potential in mitigating ROM-induced renal damage.
- Oxygen radicals influence gene transcription, impacting cellular processes.
Conclusions:
- ROMs are critical players in the pathogenesis of renal diseases.
- Targeting ROMs with antioxidants presents a potential therapeutic avenue.
- Further research into oxygen radical regulation of gene transcription is warranted.