Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calciotropic hormones and nephrolithiasis

A D'Angelo1, L Calò, S Cantaro

  • 1Institute of Internal Medicine, Division of Nephrology, University of Padua, Italy.

Mineral and Electrolyte Metabolism
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring nutraceutical solutions for prediabetes: a narrative review on the effects of banaba and chromium picolinate.

European review for medical and pharmacological sciences·2025
Same author

First Measurement of Deeply Virtual Compton Scattering on the Neutron with Detection of the Active Neutron.

Physical review letters·2024
Same author

The Impact of Oxidative Stress on Pregnancy. The Neglected Role of Alcohol Misuse.

La Clinica terapeutica·2024
Same author

What is bad news in fertility care? A qualitative analysis of staff and patients' accounts of bad and challenging news in fertility care.

Human reproduction (Oxford, England)·2023
Same author

First Measurement of Hard Exclusive π^{-}Δ^{++} Electroproduction Beam-Spin Asymmetries off the Proton.

Physical review letters·2023
Same author

First CLAS12 Measurement of Deeply Virtual Compton Scattering Beam-Spin Asymmetries in the Extended Valence Region.

Physical review letters·2023

Altered vitamin D and parathyroid hormone (PTH) interactions can cause hypercalciuria in recurrent kidney stone formers. Calcitonin also plays a role, influenced by dietary calcium, potentially impacting bone health.

Area of Science:

  • Nephrology
  • Endocrinology
  • Metabolic Bone Disease

Background:

  • Recurrent calcium stone formation involves complex hormonal interrelationships, often deviating from theoretical models.
  • The vitamin D endocrine system significantly impacts calcium metabolism and stone formation.
  • Abnormal calcitriol synthesis and parathyroid hormone (PTH) dynamics are implicated in hypercalciuria.

Purpose of the Study:

  • To elucidate the roles of vitamin D, PTH, and calcitonin in the pathogenesis of recurrent calcium nephrolithiasis.
  • To investigate the mechanisms underlying hypercalciuria and its hormonal regulation.
  • To explore the relationship between hormonal imbalances, bone demineralization, and stone formation.

Main Methods:

  • Review of existing literature on calcium-regulating hormones in stone formers.

Related Experiment Videos

  • Analysis of hormonal profiles and their correlation with clinical presentation.
  • Examination of the effects of vitamin D and PTH on calcium and oxalate excretion.
  • Assessment of calcitonin's role in relation to dietary calcium intake.

    • Main Results:

    • Abnormal vitamin D metabolism (calcitriol up-regulation) can lead to hypercalciuria and PTH suppression.
    • Thiazide diuretics may exert hypocalciuric effects by enhancing PTH response and reducing vitamin D.
    • Vitamin D negatively affects bone health during negative calcium balance and influences urinary oxalate.
    • PTH does not appear directly stimulated in hypercalciuria; bone demineralization is similar in hyperparathyroidism with or without recurrent stones.
    • Calcitonin plays a role, particularly in absorptive hypercalciuria, and is linked to dietary calcium and thyroid C-cell sensitivity.

    Conclusions:

    • Vitamin D and PTH dysregulation are key factors in hypercalciuria and recurrent calcium stones.
    • Calcitonin's role, modulated by diet and thyroid sensitivity, contributes to hypercalciuria.
    • Understanding these hormonal interactions is crucial for managing recurrent calcium nephrolithiasis and associated bone conditions.