[Differentiation effect of hexamethylene bisacetamide (HMBA) on mucoepidermoid carcinoma in vivo]

The differentiation effect of HMBA was examined in mucoepidermoid carcinoma transplanted to athymic mice. The animals were divided into HMBA and control groups. The effects were evaluated by inhibitory rate of tumor growth, the survival period and the morphological changes of cells. The results showed that the inhibitory rate of tumor growth was 71.7%, the survival period of HMBA group was 49.6 days while control group was 38.3 days, the cells of HMBA group tended to become more mature, and the mean number of AgNORs was also significantly reduced. These results indicate that HMBA can induce the MEC-1 cells to differentiate toward nomal or benign cells in vivo.