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[Regulation of epinephrine on melatonin receptor of the young mouse thymus]
1Department of Neurology, Chang Zheng Hospital, Second Military Medical University, Shanghai.
Sheng Li Xue Bao : [Acta Physiologica Sinica]
|October 1, 1996
Abstract
Unlabelled:
The melatonin binding sites in membrane preparations of the young mouse thymus were studies using [125I] iodomelatonin as the radioligand. Effect of epinephrine (E) on melatonin receptor (MR) of young mouse thymus were investigated.
Results:
(1) E had inhibitory effect on MR of mouse thymus; (2) Propranolol could reverse the inhibitory effect of E but phentolamin could not; (3) cAMP had inhibitory effect on MR. These results indicate that E has the inhibitory effect on MR of the mouse thymus and the effect was mediated by beta-adrenergic receptor.