Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Disturbances in higher function in Parkinson's disease

F Tamaru1

  • 1Department of Neurology, Nagano Red Cross Hospital, Wakasato, Nagano City, Japan.

European Neurology
|January 1, 1997
PubMed
Summary

Parkinson's disease impairs cognitive functions, particularly set-shifting ability. This study highlights the role of the dopaminergic system in these cognitive disturbances, linking substantia nigra changes to executive function deficits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive impairment in Parkinson's disease: a 6year follow-up study.

Parkinsonism & related disorders·2008
Same author

[Analysis of gait disturbance in a patient with corticobasal degeneration].

Rinsho shinkeigaku = Clinical neurology·1995
Same author

[Dementia and psychiatric disorders of Parkinson disease and their physiopathology].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·1994
Same author

[Corticobasal degeneration: clinico-pathological studies on two cases].

Rinsho shinkeigaku = Clinical neurology·1993
Same author

Sensorimotor processing in Parkinson's disease.

Advances in neurology·1993
Same author

Event-related potentials, reaction time, and cognitive state in patients with Parkinson's disease.

Advances in neurology·1993

Area of Science:

  • Neuroscience
  • Cognitive Neurology
  • Movement Disorders

Background:

  • Parkinson's disease (PD) is characterized by significant cognitive deficits, often resembling subcortical dementia.
  • A key theoretical mechanism involves the dysfunction of cortical-basal ganglionic circuits, crucial for frontal lobe functions.
  • The nigrostriatal dopaminergic system modulates these circuits, suggesting its pathological changes in PD impact cognition.

Purpose of the Study:

  • To investigate the role of the dopaminergic system in cognitive disturbances observed in Parkinson's disease.
  • To explore the specific impact of nigrostriatal pathway dysfunction on executive functions, particularly set-shifting ability.

Main Methods:

  • The study focused on analyzing the relationship between dopaminergic system changes and cognitive performance in Parkinson's disease patients.
  • Specific cognitive tests assessing executive functions, including set-shifting, were employed.

Main Results:

  • Findings indicate that the dopaminergic system is implicated in the observed cognitive deficits in Parkinson's disease.
  • The study specifically identified the dopaminergic system's role in the impairment of set-shifting ability.

Conclusions:

  • The dopaminergic system dysfunction in Parkinson's disease contributes to cognitive impairments, including executive function deficits.
  • Targeting the dopaminergic system may offer therapeutic potential for cognitive disturbances in Parkinson's disease.

Related Experiment Videos