Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angiogenesis induced by tumor-host interaction in the rat

P Matar1, G C Celoria, M T Font

  • 1Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.

Journal of Experimental & Clinical Cancer Research : CR
|December 5, 1997
PubMed
Summary

Tumor vascularization drives metastasis. This study reveals that tumor-host interactions, not just the tumor itself, dictate the intensity of new blood vessel growth (angiogenesis).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers.

Scientific reports·2023
Same author

Repositioning metformin and propranolol for colorectal and triple negative breast cancers treatment.

Scientific reports·2021
Same author

Comparative effectiveness of two metronomic chemotherapy schedules-our experience in the preclinical field.

Cancer investigation·2014
Same author

Association between baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer.

Indian journal of cancer·2013
Same author

Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas.

Annals of oncology : official journal of the European Society for Medical Oncology·2013
Same author

Regulatory T cells but not NKT I cells are modulated by a single low-dose cyclophosphamide in a B cell lymphoma tumor-model.

Experimental oncology·2012

Area of Science:

  • Oncology
  • Vascular Biology
  • Immunology

Background:

  • Tumor vascularization is critical for metastasis.
  • Understanding angiogenesis requires studying both tumor and host factors.
  • Tumor-host interactions significantly influence neovascularization.

Purpose of the Study:

  • To investigate the role of tumor-host interactions in angiogenesis.
  • To determine how host genetic background affects tumor-induced neovascularization.
  • To assess how different tumors elicit varied angiogenic responses in specific hosts.

Main Methods:

  • Utilized a rat model with two lines selected for resistance/susceptibility to specific tumors.
  • Employed two transplantable tumors: Sarcoma E100 and Lymphoma TACB.

Related Experiment Videos

  • Analyzed angiogenesis following subcutaneous implantation of tumors into different host lines.

    • Main Results:

    • The same tumor induced varying angiogenic responses depending on the host.
    • The same host exhibited different angiogenic responses to distinct tumors.
    • Tumor-host interactions were identified as key determinants of neovascularization intensity.

    Conclusions:

    • Tumor-host interactions are crucial in modulating angiogenesis.
    • The genetic makeup of the host significantly influences the angiogenic potential of a tumor.
    • Neovascularization is a dynamic process shaped by the interplay between tumor and host environments.