[Primary intracranial malignant lymphoma: report of 40 cases]

Primary intracranial malignant lymphoma is rate in clinic. But the incidence tends to be increasing recently. In its relatively short course, children and the slightly more woman headache vomiting IICP (increased intracranial pressure) and corresponding neurofunctional disorders due to various location of the tumors are the main clinical manifestation. Even high density which obviously increased after contrast and peripheral edema may be seen in CT scanning. MRI examination shows lowereal signals in T1 phase. But enhanced signals in T2 phase. Histologically the tumor mass is grayish in color often with a blussed borders (those located in brain surface often have rough borders) to the naked eye. Undermicroscope tumor cell may be seen around blood vessels with decreased cytosol, pathologic rayokinesis and somtimes focal hemorrhage necrosis. All patients in the 40 cases of our study group were connfirmed by surgical excision and patholog examination. Three patients died within half a year after resection. The others showed a survival period ranging from 4 to 20 months after postoperative irradiation solely or combined chemotherapy. Nine patients failed in total resection. Patients undergone postoperative irradiation but without following chemotherapy, only survived 4 to 9.7 months. Thus it can be seen that prolongation of the survival period of primary intracranial malignant lymphoma depends upon possibly early excision combined irradiation and effective chemotherapy.