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Modulating the transcriptional control of adipogenesis
1Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA. tloftus@welchlink.welch.jhu.edu
Current Opinion in Genetics & Development
|December 6, 1997
Abstract:
Current evidence indicates that much of the regulation of adipocyte differentiation serves to modulate a common adipogenic transcriptional control pathway, comprising members of the C/EBP and PPAR families. Hormonal regulators have been found to control expression of these factors and to alter their activity through ligand binding, post-transcriptional modification, and protein-protein interactions.