[Experimental studies on effects of excessive iodine intake on morphology and function of kidney in mice]

To understand that if excessive iodine can cause damage to tissues other than thyroid gland, mice were fed with iodine-excess water and iodine-excess goiter was caused in them. Hisitomorphology and function of the kidney, in addition to the thyroid gland, in goiter mice were observed. Results showed that two hundred days after being fed with 3,000 micrograms iodine per liter water, in addition to causing iodine-excess goiter characterized with proliferation of large amount of colloid in thyroid follicles, morphology and function of the kidneys in mice were significantly damaged, with prominent pathomorphological changes of crescent formation and metabolic inhibition in microsome membrane Na(+)-K(+)-ATPase activities in their kidneys. Na(+)-K(+)-ATPase activities were 21.95 +/- 7.50 mumolPi/mg Pr.hr in low iodine group, and 17.64 +/- 8.63 mumolPi/mg Pr.hr in excessive iodine group, with significant difference. It suggests that excessive iodine can cause damage not only to thyroid, but to the whole body.