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[Studies on the mutagenicity of artificial musk]
Abstract:
Artificial musk-raw material, using as a substitute for traditional Chinese medicine musk, a new drug of class I was assessed for mutagenicity. The micronucleus rates of polychromatocyte in the bone marrow of mice were 2.8, 1.3 and 1.0/1000 when the treated dosage was 1800, 700 and 350 mg/kg. The results of Ames test for the strains TA97, TA98, TA100 and TA102 were negative with and without S9 mix when the concentration of artificial musk was 625, 1,250, 2,500 and 5,000 micrograms/plate, respectively. The chromosome aberration rates were 1.0, 0.8, 1.2% when the treated dosage was 360, 180, 90 mg/kg, respectively. The above results proved that no mutagenicity was found for artificial musk.
Insights
Artificial musk, a substitute for traditional musk, was evaluated for mutagenicity. Studies confirmed that artificial musk does not exhibit mutagenic properties, indicating its safety for use.
Area of Science:
- Toxicology
- Pharmacology
Context:
- Artificial musk is increasingly used as a substitute for traditional musk in various applications.
- Assessing the safety profile of pharmaceutical ingredients is crucial for drug development.
Purpose:
- To evaluate the mutagenicity of artificial musk, a Class I new drug.
- To determine if artificial musk poses a genotoxic risk.
Summary:
- In vivo micronucleus tests in mice showed no significant increase in micronucleus rates at dosages up to 1800 mg/kg.
- In vitro Ames tests using bacterial strains TA97, TA98, TA100, and TA102 yielded negative results for mutagenicity.
- Chromosome aberration tests also indicated no significant genotoxic effects at tested concentrations.
Impact:
- The findings support the safety of artificial musk as a pharmaceutical ingredient.
- This research contributes to the risk assessment of synthetic compounds used in medicine.