Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does nitrous oxide antagonize sevoflurane-induced hypnosis?

T Katoh1, K Ikeda, H Bito

  • 1Department of Anaesthesiology and Intensive Care Medicine, Hamamatsu University School of Medicine, Japan.

British Journal of Anaesthesia
|December 6, 1997
PubMed
Summary

Nitrous oxide significantly reduces the sevoflurane concentration needed to prevent movement in response to verbal commands (MACawake). This effect was non-linear, with nitrous oxide antagonizing sevoflurane at higher concentrations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.

Science (New York, N.Y.)·2019
Same author

Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders.

Translational psychiatry·2017
Same author

Remifentanil-based anaesthesia increases the incidence of postoperative surgical site infection.

The Journal of hospital infection·2014
Same author

Quantification of the degradation products of sevoflurane using four brands of CO2 absorbent in a standard anesthetic circuit.

Journal of anesthesia·2003
Same author

Effects of sevoflurane anesthesia on plasma inorganic fluoride concentrations during and after cardiac surgery.

Journal of anesthesia·2003
Same author

Effect of the neuronal nitric oxide synthase inhibitor 7-nitroindazole on the righting reflex ED50 and minimum alveolar concentration during sevoflurane anaesthesia in rats.

European journal of anaesthesiology·2003

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Sevoflurane is a widely used inhalation anesthetic.
  • Understanding drug interactions is crucial for optimizing anesthetic delivery.

Purpose of the Study:

  • To determine the effect of varying nitrous oxide concentrations on the minimum alveolar concentration of sevoflurane required to prevent movement in response to verbal commands (MACawake).

Main Methods:

  • 64 ASA I and II patients (20-60 yr) were randomly assigned to 0%, 20%, 40%, or 60% nitrous oxide groups.
  • Sevoflurane end-tidal concentrations were adjusted to determine MACawake.
  • Patients were assessed for wakefulness or sleep after steady-state anesthetic concentrations were achieved.

Main Results:

  • The sevoflurane MACawake was 0.63%.

Related Experiment Videos

  • Increasing nitrous oxide concentration non-linearly reduced sevoflurane MACawake.
  • A nitrous oxide concentration of 45% produced a 50% reduction in sevoflurane MACawake.
  • The interaction between nitrous oxide and sevoflurane was antagonistic (interaction coefficient < 0, P = 0.0238).

    • Conclusions:

    • Nitrous oxide significantly reduces sevoflurane MACawake in a non-linear, antagonistic manner.
    • This suggests that nitrous oxide may antagonize sevoflurane's effect on preventing response to verbal commands.