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Radioimmunoassay of antidiuretic hormone during morphine anaesthesia
Canadian Anaesthetists' Society Journal
|May 1, 1976
Abstract:
The effect of morphine anaesthesia on plasma antidiuretic hormone levels was studied in seven adult patients. Measurements of ADH showed no significant change with morphine and 50 per cent nitrous oxide. Significant elevation occurred with surgical stimulation as previously reported. Changes in urine flow with high doses of morphine are then not ADH related.
Insights
Morphine anesthesia did not significantly alter antidiuretic hormone (ADH) levels. Surgical stress, however, elevated ADH, indicating urine flow changes with high morphine doses are not ADH-dependent.
Area of Science:
- Anesthesiology
- Endocrinology
- Nephrology
Background:
- Antidiuretic hormone (ADH) plays a crucial role in regulating body fluid balance.
- Understanding the impact of anesthetic agents on hormonal regulation is vital for patient care.
Purpose of the Study:
- To investigate the effect of morphine anesthesia on plasma antidiuretic hormone (ADH) levels in adult patients.
- To differentiate the effects of morphine from surgical stimulation on ADH secretion.
Main Methods:
- Plasma ADH levels were measured in seven adult patients undergoing anesthesia.
- Patients received morphine and 50% nitrous oxide.
- ADH levels were assessed before and during surgical stimulation.
Main Results:
- Morphine anesthesia, alone or with nitrous oxide, did not cause significant changes in plasma ADH levels.
- Surgical stimulation led to a significant elevation in plasma ADH levels, consistent with prior research.
- The study found no correlation between urine flow changes and ADH levels when high doses of morphine were administered.
Conclusions:
- Morphine anesthesia does not appear to significantly affect antidiuretic hormone secretion.
- Surgical stress is a potent stimulus for ADH release, independent of morphine.
- Changes in urine output during high-dose morphine anesthesia are likely mediated by mechanisms other than alterations in ADH levels.