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Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study
L N Weckstein1, A Jacobson, D Galen
1Reproductive Science Center of the Bay Area Fertility and Gynecology Medical Group, San Ramon, California, USA.
Objective:
To evaluate the effect of low-dose aspirin use in oocyte donation recipients with an endometrial thickness of < 8 mm.
Design:
A prospective, randomized study.
Setting:
An oocyte donation program in a private infertility practice.
Patient(S):
Twenty-eight recipients undergoing oocyte donation who failed to develop an endometrial thickness of at least 8 mm in a previous evaluation cycle.
Intervention(S):
Fifteen recipients received low-dose aspirin (81 mg/d) in addition to standard hormone replacement for an oocyte donation cycle. The remaining 13 recipients did not receive aspirin.
Main Outcome Measure(S):
Clinical pregnancy rates, delivery rates, implantation rates, and change in endometrial thickness were compared in the aspirin and nonaspirin groups.
Result(S):
There was no demonstrable increase in endometrial thickness in the aspirin-treated group. However, there was a statistically significant increase in implantation rates in the aspirin-treated group (24% versus 9%) and in implantation rates and clinical pregnancy rates in the aspirin-treated group when the final endometrial thickness was < 8 mm.
Conclusion(S):
Low-dose aspirin therapy improves implantation rates in oocyte donation recipients with a thin endometrium.