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Related Experiment Videos

TRANSFAC database as a bridge between sequence data libraries and biological function

E Wingender1, H Karas, R Knüppel

  • 1Gesellschaft für Biotechnologische Forschung mbH, Braunschweig.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
|January 1, 1997
PubMed
Summary
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The TRANSFAC database provides a dictionary of regulatory DNA sequences and transcription factors. This resource aids in identifying biological functions and regulatory signals within genomic sequences.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Regulatory DNA sequences control gene expression.
  • Transcription factors are proteins that bind to DNA to regulate transcription.
  • Understanding these interactions is crucial for deciphering gene regulation.

Purpose of the Study:

  • To describe the TRANSFAC database as a resource for regulatory DNA and transcription factor information.
  • To highlight the utility of TRANSFAC for defining sequence elements and identifying regulatory signals.

Main Methods:

  • The TRANSFAC database compiles information on regulatory DNA elements.
  • It includes data on transcription factors that bind to these elements.
  • The database facilitates the creation of consensus sequences and matrices.

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Main Results:

  • TRANSFAC serves as a dictionary for the biological meaning of DNA sequence elements.
  • It enables the description and functional characterization of regulatory elements.
  • The data supports the identification of regulatory signals in new genomic sequences.

Conclusions:

  • TRANSFAC is a valuable resource for understanding gene regulation.
  • It aids researchers in analyzing and interpreting genomic sequences.
  • The database facilitates the discovery of functional regulatory elements.