Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The inherited palmoplantar keratodermas

R C Ratnavel1, W A Griffiths

  • 1St. John's Institute of Dermatology, St Thomas' Hospital, London, UK.

The British Journal of Dermatology
|December 9, 1997
PubMed
Summary

Inherited palmoplantar keratodermas (PPK) are complex skin disorders. Advances in molecular biology are enabling a new classification based on genetic causes, improving disease management strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blistering disease in a child.

Clinical and experimental dermatology·2006
Same author

Case 3: widespread scaly papules affecting a patient's limbs and pinnae giving the skin a rough feeling. Diagnosis: Flegel's disease. Syn. hyperkeratosis lenticularis perstans.

Clinical and experimental dermatology·2003
Same author

Antibiotic-resistant cellulitis acquired in Turkey.

Journal of the Royal Society of Medicine·2003
Same author

Multiple squamous skin carcinomas following excess sunbed use.

Journal of the Royal Society of Medicine·2001
Same author

[Pityriasis rubra pilaris].

Annales de dermatologie et de venereologie·2001
Same author

New mutations in keratin 1 that cause bullous congenital ichthyosiform erythroderma and keratin 2e that cause ichthyosis bullosa of Siemens.

The British journal of dermatology·2001

Area of Science:

  • Dermatology
  • Genetics
  • Molecular Biology

Background:

  • Inherited palmoplantar keratodermas (PPK) represent a diverse group of genodermatoses.
  • Clinical classification of PPK is challenging due to their heterogeneity.

Purpose of the Study:

  • To review recent advances in understanding the genetic basis of PPK.
  • To explore the implications of molecular pathology for PPK classification and management.

Main Methods:

  • Review of current research in molecular biology and genetics related to PPK.
  • Analysis of recent findings on the genetic underpinnings of palmoplantar keratodermas.

Main Results:

  • Molecular biology techniques are significantly enhancing the understanding of PPK genetic etiologies.
  • This increased genetic knowledge facilitates a shift towards molecular pathology-based classification.

Conclusions:

  • Molecular insights are crucial for refining the classification of inherited palmoplantar keratodermas.
  • Advances in genetic understanding pave the way for novel therapeutic and management strategies for PPK.

Related Experiment Videos