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Ventilation distribution during histamine provocation

S Verbanck1, D Schuermans, A Van Muylem

  • 1Academisch Ziekenhuis, Vrije Universiteit Brussel, 1090 Brussels, Belgium. pnevks@az.vub.ac.be

Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 14, 1998
PubMed
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Inhaled histamine causes significant ventilation inhomogeneity in the small airways of asymptomatic individuals. This study reveals inhomogeneous narrowing of airways proximal to the acinar zone, impacting lung function.

Area of Science:

  • Pulmonary Physiology
  • Respiratory Medicine
  • Lung Function Testing

Background:

  • Ventilation inhomogeneity can occur in asymptomatic individuals.
  • Histamine provocation is used to assess airway responsiveness.
  • N2 multiple-breath washout (MBW) measures ventilation distribution.

Purpose of the Study:

  • To investigate ventilation inhomogeneity in asymptomatic subjects after histamine provocation.
  • To differentiate responders and nonresponders based on lung function changes.
  • To assess ventilation distribution in conductive and acinar zones.

Main Methods:

  • Recruited 20 asymptomatic, nonsmoking subjects.
  • Administered inhaled histamine provocation.
  • Utilized N2 multiple-breath washout (MBW) to measure Scond and Sacin.

Related Experiment Videos

  • Defined responders by a ≥20% decrease in forced expiratory volume in 1 second (FEV1).

    • Main Results:

    • Responders showed a 26% FEV1 decrease and a 390% Scond increase.
    • Nonresponders had an 11% FEV1 decrease and a 198% Scond increase.
    • Sacin remained unchanged in both groups, but baseline Sacin was higher in responders.

    Conclusions:

    • Histamine provocation induces significant ventilation inhomogeneity in the conductive airways.
    • Small airway narrowing occurs proximal to the acinar zone.
    • Inhomogeneous airway narrowing, not just caliber reduction, contributes to altered lung function.