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Acute hyperglycaemia affects anorectal motor and sensory function in normal subjects
A Russo1, W M Sun, Y Sattawatthamrong
1University Department of Medicine, Royal Adelaide Hospital, Australia.
Gut
|December 10, 1997
Summary
High blood glucose levels impair anal sphincter function and increase rectal sensitivity in healthy individuals. However, normal blood glucose fluctuations do not significantly affect anorectal function.
Area of Science:
- Gastroenterology
- Physiology
- Endocrinology
Background:
- Anorectal dysfunction is common in diabetes mellitus, but its cause is unclear.
- Blood glucose levels reversibly impact gastrointestinal motility.
Purpose of the Study:
- To investigate the effects of varying blood glucose levels (4, 8, and 12 mmol/l) on anorectal motor and sensory function in healthy subjects.
Main Methods:
- Eight healthy subjects underwent anorectal manometry and electromyography.
- Measurements were taken at stabilized blood glucose concentrations of 4, 8, and 12 mmol/l.
Main Results:
- Elevated blood glucose (12 mmol/l) increased spontaneous anal relaxations and rectal compliance.
- High glucose levels reduced anal squeeze pressures and lowered the threshold for rectal distension perception.
- No significant differences in residual anal pressures were observed across glucose levels.
Conclusions:
- Acute hyperglycemia (12 mmol/l) inhibits anal sphincter function and heightens rectal sensitivity in normal individuals.
- Physiological blood glucose variations do not significantly alter anorectal motor and sensory function.
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