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Updated: Oct 7, 2026

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.
Published on: September 18, 2014
Gastrin-releasing peptide1-27, unlike bombesin, does not reduce sham feeding in rats
J Smith1, S Perez, P A Rushing
1Department of Psychiatry, Cornell University Medical College, NY, USA.
Abstract:
We compared the potencies of systemic administration of bombesin (BN) and its mammalian homologue gastrin-releasing peptide (GRP) to decrease sham feeding in rats. Bombesin (at doses of 8, 16 and 32 micrograms/kg, intraperitoneally) inhibited sham feeding by 37% (p < 0.001), 58% (p < 0.001) and 65% (p < 0.001), respectively, confirming previous results. Gastrin-releasing peptide (16, 32, and 64 micrograms/kg) failed to affect sham feeding. Bombesin (16 micrograms/kg) and gastrin-releasing peptide (32 micrograms/kg) inhibited real feeding by 64% (p < 0.001) and 44% (p < 0.004), respectively. Pregastric food stimulation is not sufficient for the inhibitory action of GRP.
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