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Diffuse cystic change of a term placenta with a normal newborn
N Uemura1, F Kobayashi, D Korita
1Department of Obstetrics and Gynaecology, Hyogo Prefectural Amagasaki Hospital, Amagasaki, Japan.
The Journal of Obstetrics and Gynaecology Research
|December 11, 1997
Summary
This case study describes a term placenta with diffuse cystic villous lesions, distinct from trophoblastic disease. The placental changes were likely secondary to altered local circulation.
Area of Science:
- Obstetrics and Gynecology
- Pathology
- Fetal Medicine
Background:
- A term placenta presented with diffuse cystic lesions resembling hydatidiform moles.
- The patient was a 19-year-old primipara at 36 weeks gestation.
Observation:
- Macroscopic examination revealed multiple cystic lesions (3-8 mm) on the placenta.
- Histopathology showed severe hydropic change localized to stem villi, sparing terminal villi.
- Abnormal trophoblast proliferation was absent.
Findings:
- Hypertrophic changes in the stem villi vascular walls with smooth muscle-like cell hyperplasia were noted.
- Urinary human chorionic gonadotropin (hCG) levels were normal post-delivery (<50 IU/l).
- These placental findings differ significantly from trophoblastic disease.
Implications:
- The diffuse cystic villous lesions are not indicative of trophoblastic disease.
- The observed placental pathology may be a consequence of local circulatory disturbances.