Related Experiment Video
Updated: Aug 7, 2026
09:29
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Tumour bed positivity predicts outcome after breast-conserving surgery
R D Macmillan1, A D Purushotham, E Mallon
1University Department of Surgery, Western Infirmary, Glasgow, UK.
The British Journal of Surgery
|December 11, 1997
Summary
Minimally invasive cavity shaving for breast cancer surgery significantly reduces local recurrence by assessing the tumor bed. This technique helps identify residual disease, improving long-term outcomes for patients.
Area of Science:
- Oncology
- Surgical Pathology
- Breast Cancer Research
Background:
- Local recurrence after breast-conserving surgery (BCS) is linked to poorer distant disease-free survival.
- Early recurrence often stems from residual disease at the surgical site.
- Tumor bed positivity is a frequent post-BCS finding.
Purpose of the Study:
- To evaluate the efficacy of the cavity shaving technique for tumor bed analysis in BCS.
- To determine the impact of tumor bed status on recurrence rates.
- To assess the local and distant recurrence rates following BCS with cavity shaving and selective re-excision.
Main Methods:
- A cohort of 300 patients undergoing BCS had their tumor beds analyzed using the cavity shaving technique.
- All patients received postoperative radiotherapy.
- Follow-up averaged 4.4 years.
Main Results:
- Tumor bed positivity was observed in 39.3% of patients.
- A selective re-excision strategy resulted in a 2.0% local recurrence rate and a 10.4% distant recurrence rate.
- Multivariate analysis identified lymphovascular invasion, estrogen receptor status, and tumor bed status as independent predictors of distant recurrence.
Conclusions:
- The cavity shaving technique for margin assessment can achieve low local recurrence rates after BCS.
- Tumor bed status is a valuable prognostic indicator in patients undergoing BCS.
More Related Videos
Related Concept Videos
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:21Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...