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Hypersensitivity to prilocaine

K Göransson

    Dermatologica
    |January 1, 1976
    PubMed
    Summary

    A rare late-onset anaphylactoid reaction to prilocaine was observed. Intracutaneous testing confirmed the patient's sensitivity to this local anesthetic, highlighting a delayed hypersensitivity response.

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    Area of Science:

    • Anesthesiology
    • Allergy and Immunology

    Background:

    • Prilocaine is a commonly used local anesthetic.
    • Adverse reactions to local anesthetics can occur, though typically immediate.
    • Late-onset hypersensitivity reactions are less commonly reported.

    Observation:

    • A patient presented with symptoms suggestive of an anaphylactoid reaction.
    • The reaction manifested after a delay following prilocaine administration.
    • Intracutaneous testing was performed to evaluate sensitivity.

    Findings:

    • The intracutaneous test for prilocaine was positive.
    • This finding supports a diagnosis of late-onset anaphylactoid reaction to prilocaine.
    • The case demonstrates a delayed hypersensitivity mechanism.

    Implications:

    • Clinicians should consider delayed hypersensitivity to prilocaine in cases of late-onset reactions.
    • Positive intracutaneous testing can aid in diagnosing anesthetic-related allergies.
    • Further research may be warranted to understand the mechanisms of late-onset reactions to local anesthetics.

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