Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oral bioavailability and first-pass effects

K C Kwan1

  • 1Merck Research Laboratories, West Point, PA 19486, USA.

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|January 31, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transition of lasing modes in disordered active photonic crystals.

Optics letters·2007
Same author

A commentary: methods and assumptions in the kinetic estimation of metabolite formation.

Drug metabolism and disposition: the biological fate of chemicals·1983
Same author

Elementary osmotic pump for indomethacin.

Journal of pharmaceutical sciences·1983
Same author

Kinetics of osmotically controlled indomethacin delivery systems after repeated dosing.

Clinical pharmacology and therapeutics·1982
Same author

Stereoselectivity in the disposition and metabolism of the uricosuric-diuretic agent, indacrinone, in Rhesus monkeys.

Drug metabolism and disposition: the biological fate of chemicals·1982
Same author

A liner mode of reversible metabolism and its application to bioavailability assessment.

Journal of pharmacokinetics and biopharmaceutics·1981
Same journal

Construction of a curated human pharmacokinetics database for molecular fragment analysis and machine learning applications.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same journal

Finding the dispersion number (D<sub>N</sub>) of the dispersion model from perfused rat and human liver studies.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same journal

Role of organic anion transporting polypeptides in pancreatic statin disposition and islet cell function in mice.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same journal

The regulatory potential of cytochrome P450-adrenodoxin interactions: Insights toward understanding redox partner regulation in drug metabolizing enzymes.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same journal

Enantioselective determination of methylone and its major phase 1 metabolites in various biological matrices and stereochemical stability of methylone enantiomers.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same journal

Population pharmacokinetics and resistance patterns of vancomycin and amikacin in pediatric oncology patients.

Drug metabolism and disposition: the biological fate of chemicals·2026
See all related articles

This study reviews in vivo methods to assess oral drug bioavailability, providing a framework to quantify absorption, gut losses, and first-pass metabolism. These strategies enable accurate evaluation of drug and metabolite bioavailability.

Area of Science:

  • Pharmacokinetics and Drug Metabolism
  • Bioavailability Assessment

Background:

  • Evaluating factors influencing oral bioavailability in vivo is crucial for drug development.
  • Current experimental strategies require integration for a comprehensive understanding.

Purpose of the Study:

  • To review existing in vivo methods for assessing oral bioavailability.
  • To propose an integrated strategy for quantifying absorption, gut losses, and first-pass elimination.
  • To enable assessment of metabolite bioavailability and sites of biotransformation.

Main Methods:

  • Review of existing experimental strategies for in vivo oral bioavailability evaluation.
  • Development of an integrated set of strategies based on evolved concepts.
  • Application of methods under assumptions of linear pharmacokinetics and constant clearance.

Related Experiment Videos

Main Results:

  • An integrated strategy capable of estimating individual contributions to oral bioavailability.
  • Quantification of absorption, gut lumen losses, and first-pass elimination (gut wall and liver).
  • Suitability for assessing metabolite bioavailability and determining biotransformation sites.

Conclusions:

  • The proposed integrated strategy offers a robust framework for in vivo oral bioavailability assessment.
  • This approach allows for detailed analysis of drug and metabolite disposition.
  • Accurate determination of bioavailability factors and metabolic pathways is achievable.