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Chitosan: properties, preparations and application to microparticulate systems

H S Kaş1

  • 1Hacettepe University, Pharmacy Faculty, Pharmaceutical Technology Department, Ankara, Turkey.

Journal of Microencapsulation
|December 12, 1997
PubMed
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This review explores chitosan-based microparticles, highlighting their versatile properties and diverse applications, particularly in pharmaceutical and biopharmaceutical fields. We examine preparation methods and their potential for drug delivery systems.

Area of Science:

  • Biopolymer Science
  • Materials Science
  • Pharmaceutical Science

Background:

  • Chitosan is a natural, non-toxic, biodegradable polysaccharide derived from chitin.
  • It exhibits hydrophilic properties and is available in various forms like powder, bead, and fiber.
  • Extensive research covers chitosan's sources, biochemistry, structure, modifications, properties, and applications.

Purpose of the Study:

  • To review the attractive properties of chitosan-based microparticles.
  • To discuss their versatile characteristics and various preparation methods.
  • To highlight their significant pharmaceutical and biopharmaceutical applications.

Main Methods:

  • Literature review of scientific publications on chitosan-based microparticles.
  • Analysis of studies detailing preparation techniques.

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  • Synthesis of information on functional properties and applications.

    • Main Results:

    • Chitosan microparticles possess versatile properties suitable for advanced applications.
    • Various methods exist for preparing chitosan microparticles, influencing their characteristics.
    • Significant potential exists for chitosan microparticles in drug delivery and biopharmaceutical formulations.

    Conclusions:

    • Chitosan-based microparticles offer a promising platform for pharmaceutical and biopharmaceutical innovations.
    • Further research into preparation methods can optimize microparticle properties for specific applications.
    • Their biocompatibility and biodegradability underscore their value in biomedical fields.