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Related Experiment Videos

Patterns of nitric oxide synthase expression in the developing superior colliculus

R Mendez-Otero1, F Tenorio, A Giraldi-Guimarães

  • 1Departamento de Histologia, ICB, Universidade Federal do Rio de Janeiro, Brazil. rmotero@ibccf.biof.ufrj.br

Revista Brasileira De Biologia
|December 1, 1996
PubMed
Summary

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Nitric oxide synthase (NOS) is present in the developing rat superior colliculus, with expression increasing after birth and paralleling neural pathway development. This suggests NOS-positive cells play a role in synaptic plasticity during development.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Histochemistry

Background:

  • Nitric oxide (NO) is a signaling molecule in the nervous system implicated in synaptic plasticity.
  • Nitric oxide synthase (NOS) produces NO and can be visualized using NADPH-d histochemistry.

Purpose of the Study:

  • To investigate the presence and developmental expression of NOS in the rat superior colliculus.
  • To correlate NOS expression patterns with developmental events in the superior colliculus.

Main Methods:

  • Utilized NADPH-d histochemistry to detect NOS-positive cells and neuropil.
  • Examined NOS expression in the superior colliculus from postnatal day 7 through adulthood.

Main Results:

  • NOS-positive cells and neuropil were observed in the developing and adult rat superior colliculus.

Related Experiment Videos

  • NOS expression began at postnatal day 7, increased to a peak by day 15, and reached adult levels by the third postnatal week.
  • All cell types in the superior colliculus expressed NOS, with cells exhibiting Golgi-like morphology.

    • Conclusions:

    • NOS expression in the superior colliculus follows a developmental trajectory that parallels the maturation of visual pathways.
    • NOS-positive cells are likely involved in synaptic plasticity and the functional development of the superior colliculus.