Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fixed drug eruption from amoxycillin

I Jiménez1, E Antón, I Picáns

  • 1Allergy Section, Marqués de Valdecilla Hospital, Santander, Spain.

Allergologia Et Immunopathologia
|December 12, 1997
PubMed
Summary

Fixed drug eruption on the genital mucosa caused by amoxicillin was observed. Oral challenge confirmed amoxicillin as the trigger, with no cross-reactivity to other beta-lactams like phenoxymethylpenicillin or cephalexin.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Open fracture of the distal radius with complete laceration of the median nerve.

Acta ortopedica mexicana·2025
Same author

Types, behaviour and therapeutic requirements of inflammatory pouch disorders: Results from the RESERVO study of GETECCU.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2024
Same author

[Translated article] The haematoma block is not enough as method of anaesthesia in reduction of displaced distal radius fractures.

Revista espanola de cirugia ortopedica y traumatologia·2023
Same author

Fluid challenges in operating room: A planned sub study of the Fluid Day observational study.

Revista espanola de anestesiologia y reanimacion·2023
Same author

The hematoma block is not enough as method of anesthesia in reduction of displaced distal radius fractures.

Revista espanola de cirugia ortopedica y traumatologia·2023
Same author

Time to match; when do homologous chromosomes become closer?

Chromosoma·2022

Area of Science:

  • Dermatology
  • Allergology
  • Pharmacology

Background:

  • Fixed drug eruption (FDE) is a rare adverse drug reaction characterized by the recurrence of a skin lesion at the same site with re-exposure to the causative agent.
  • Amoxicillin, a widely used antibiotic, is occasionally implicated in FDE, though documented cases are scarce.

Observation:

  • A case of FDE localized to the genital mucosa (glans penis) induced by amoxicillin is presented.
  • Topical provocation with amoxicillin did not elicit a reaction.
  • Oral challenge with amoxicillin resulted in pruritic erythema on the glans penis approximately 6 hours post-ingestion.

Findings:

  • The patient tolerated phenoxymethylpenicillin, which shares a similar nuclear structure with amoxicillin, indicating no cross-reactivity.

Related Experiment Videos

  • Cephadroxil, a cephalosporin with an identical side chain to amoxicillin, was also well-tolerated.
  • This case adds to the limited literature on amoxicillin-induced FDE, with only three prior reports identified.

    • Implications:

    • This case highlights the importance of considering amoxicillin as a potential cause of genital FDE.
    • Diagnostic strategies for FDE should include careful history taking and targeted drug challenges.
    • Understanding cross-reactivity patterns within beta-lactam antibiotics is crucial for safe prescribing in patients with penicillin allergies.