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Update on intraoperative analysis of mandibular margins
L A Forrest1, D E Schuller, B Karanfilov
1Department of Otolaryngology, Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Research Institute, Ohio State University, Columbus, USA.
American Journal of Otolaryngology
|December 12, 1997
Summary
Frozen section analysis of mandibular bone margins provides accurate assessment during composite resections for carcinoma. This rapid evaluation helps oncologic surgeons ensure adequate surgical margins, improving cancer eradication.
Area of Science:
- Oncology
- Surgical Pathology
- Oral and Maxillofacial Surgery
Background:
- Evaluating bone margins during composite resections for carcinoma is challenging.
- Standard decalcification for bone pathology is time-consuming.
Purpose of the Study:
- To assess the adequacy of surgical resection by evaluating bone margins.
- To investigate frozen-section analysis as a rapid method for evaluating mandibular resection adequacy.
Main Methods:
- Histologically proven methods of cortical invasion and spread were used.
- Frozen-section analysis of cancellous bone was compared to permanent section analysis and decalcified specimens.
- 66 patients undergoing mandibular resection, with 30 cases of proven mandibular invasion, were analyzed.
Main Results:
- Complete correlation was observed between frozen and permanent section results.
- Frozen section analysis correctly predicted the adequacy of resection in 60 out of 61 margins.
Conclusions:
- Frozen section analysis allows oncologic surgeons to evaluate bone margins intraoperatively.
- This enables timely adjustments to the excision, enhancing disease eradication.