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Electroconvulsive therapy vs. paroxetine in treatment-resistant depression -- a randomized study
H W Folkerts1, N Michael, R Tölle
1Department of Psychiatry, University of Münster, Germany.
Acta Psychiatrica Scandinavica
|December 12, 1997
Summary
Electroconvulsive therapy (ECT) is more effective than paroxetine for treating major depression that resists medication. ECT demonstrated faster and more significant symptom reduction in patients with treatment-resistant depression.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Research
Background:
- Major depression treatment resistance is a common reason for electroconvulsive therapy (ECT) use.
- Few studies compare ECT efficacy against newer antidepressants like selective serotonin reuptake inhibitors (SSRIs).
Purpose of the Study:
- To compare the efficacy of right unilateral (RUL) ECT versus paroxetine in patients with medication-resistant major depression.
Main Methods:
- 39 subjects with major depression and treatment resistance were randomized to RUL ECT (n=21) or paroxetine (n=18).
- Hamilton Depression Rating Scale (HAMD) scores were used to measure treatment response.
Main Results:
- ECT group showed a 59% reduction in HAMD scores, compared to 29% in the paroxetine group (P<0.001).
- 71% of subjects in the ECT group met response criteria (≥50% HAMD score decrease).
Conclusions:
- ECT is superior to paroxetine for both the degree and speed of response in medication-resistant major depression.