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Effect of Ca2+-channel blockers on isoprenaline-induced desensitization in rat trachea
1Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Life Sciences
|January 1, 1997
Abstract:
Isoprenaline-induced desensitization in vitro in rat trachea was studied in the presence of the Ca2+-channel blockers (Ca2+-CBs) verapamil and nitrendipine. The concentration-response curves for isoprenaline were determined in a noncumulative manner using carbachol as contracting agent, and then desensitization was achieved by 40-min incubation of the tracheal preparations with isoprenaline (1 microM). The effect of verapamil and nitrendipine was studied by the addition of each Ca2+-CB to the desensitizing solution. Both verapamil and nitrendipine reduced the isoprenaline-induced desensitization in the rat trachea.