Intracellular cations and hypertension in blacks

Considerable attention has been focused in recent years on the role of intracellular ions in the pathophysiology of hypertension in African Americans. Following the identification of marked differences in red cell sodium content and sodium-lithium counter-transport between blacks and whites, the hypothesis emerged that cation metabolism at the cellular level might account for part of the ethnic difference in susceptibility to hypertension. Unfortunately, findings in the red cell have not significantly increased our understanding of the physiologic pathways and may prove to be anomalous. Interest has recently shifted to calcium metabolism, because of its greater physiologic relevance, and a new series of questions are being defined. With the development of fluoroprobes to measure sodium and calcium simultaneously, wider application of pharmacologic agonists and the use of single cell techniques have provided a new direction for this field. Whether the ethnic contrasts observed for sodium in the red cell can be reproduced in platelets remains to be seen. It may be that the earlier red cell differences were epiphenomena, unrelated to the control of blood pressure, and that the more closely one approaches basic physiologic mechanisms, the greater the cross-ethnic group similarity. Rather than drawing attention to unusual phenotypic characteristics, the study of hypertension in blacks may be more instructive for the insight it provides into the basic physiology of this disorder, common to all ethnic groups.