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A case of episodic angioedema associated with eosinophilia
T Shikiji1, Y Urano, H Takiwaki
1Department of Dermatology, University of Tokushima School of Medicine, Japan.
Background:
Gleich et al. first described 4 cases of episodic angioedema associated with eosinophilia as a distinct entity in 1984. Since then, several cases of this disorder have been reported in the United States, Europe and Japan.
Observations:
We report a case of a 22-year-old pregnant Japanese woman with this disorder. She had no fever and her general condition was good except the angioedema which was limited to her limbs. During an acute episode, her white blood cell count increased to 29,500/mm3 with 50% eosinophils, following an elevated serum interleukin-5 (IL-5) level. Spontaneous resolution occurred in 1 month after the onset. In a 5 month follow-up, no evidence of cardiac or other visceral organ involvement was found, and no recurrence occurred.
Conclusions:
Our case, combined with those reported in the literature, suggests that Japanese cases of episodic angioedema associated with eosinophilia differ from Caucasian cases in clinical symptoms and some other points.