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Tumor necrosis factor-alpha gene polymorphism in psoriasis

A I Arias1, B Giles, T H Eiermann

  • 1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston 29425-2230, USA.

Experimental and Clinical Immunogenetics
|January 1, 1997
PubMed
Summary

Genetic variations in the tumor necrosis factor-alpha (-238) gene impact psoriasis risk. Specifically, TNF-G,A heterozygosity increases susceptibility to type I psoriasis, while TNF-G homozygosity suggests resistance.

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Area of Science:

  • Immunogenetics
  • Dermatology

Background:

  • Psoriasis is an inflammatory autoimmune disease.
  • Elevated tumor necrosis factor-alpha (TNF-alpha) is observed in psoriatic lesions.

Purpose of the Study:

  • To investigate the association between TNF-alpha promoter polymorphisms (-308 and -238) and psoriasis in Caucasian patients.

Main Methods:

  • Genotyping of TNF-alpha promoter polymorphisms at positions -308 and -238.
  • Comparison of allele and genotype frequencies between 99 Caucasian psoriasis patients (type I and type II) and 123 controls.

Main Results:

  • A significant difference in the TNF-alpha -238 polymorphism distribution was found in type I psoriasis patients compared to controls.
  • Homozygosity for the TNF-G allele at -238 was decreased in patients (55% vs. 91%), indicating resistance.

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  • Heterozygosity for TNF-G,A at -238 was increased in patients (41% vs. 8%), indicating susceptibility.

    • Conclusions:

    • The TNF-alpha -238 polymorphism is associated with type I psoriasis susceptibility.
    • TNF-G homozygosity confers a lower risk (resistance), while TNF-G,A heterozygosity confers an increased risk (susceptibility) for type I psoriasis.