Red cell and platelet kinetics in chronic cytopenias following transplantation

Thirty seven patients with unexplained anemia and/or thrombocytopenia after bone marrow, kidney, liver or heart transplantation were referred to the Department of Nuclear Medicine for erythrocyte or platelet kinetic studies in order to determine the mechanism of the cytopenia: accelerated destruction, or production defect. We observed only one definite case of thrombocytopenia due to accelerated autologous platelet destruction, while the life span was normal in the other 16 cases. Anemia was due to accelerated hemolysis in 7 cases, while the red blood cell life-span was normal in 12 other cases. Kinetic studies can therefore be useful, by demonstrating the mechanism of cytopenia observed after transplantation, and by facilitating the choice of appropriate treatment.