Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acetylcholine and associative memory in the piriform cortex

E Barkai1, M H Hasselmo

  • 1Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel.

Molecular Neurobiology
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ergodic properties of Brownian motion under stochastic resetting.

Physical review. E·2024
Same author

Restart Expedites Quantum Walk Hitting Times.

Physical review letters·2023
Same author

Measurement-induced quantum walks.

Physical review. E·2022
Same author

Cusp of Non-Gaussian Density of Particles for a Diffusing Diffusivity Model.

Entropy (Basel, Switzerland)·2021
Same author

Hitchhiker model for Laplace diffusion processes.

Physical review. E·2020
Same author

Infinite ergodic theory for heterogeneous diffusion processes.

Physical review. E·2019
Same journal

Microplastic-Induced Disruption of Intestinal Barrier Integrity and Triggering Neuroinflammatory Responses Through Gut-Brain Axis Dysregulation Mediated by NF-κB/PPAR-γ/BDNF Signalling Pathways.

Molecular neurobiology·2026
Same journal

Dissecting PANoptosis in the Nervous System: A Unified Cell-Death Mechanism Driving Neuroimmune Activation and Chronic Neuroinflammation.

Molecular neurobiology·2026
Same journal

Exerkine-Mediated Regulation of the NLRP3 Inflammasome in Neuroprotection: Mechanistic Insights and the Role of Exercise.

Molecular neurobiology·2026
Same journal

miR-6836-5p Drives Astrocyte Pro-survival Signaling Through DLG2-Hippo-YAP Pathway Under AQP4-IgG + ve NMOSD Stress.

Molecular neurobiology·2026
Same journal

Nrf2 Activators in Parkinson's Disease: Modulating Mitophagy and Regulating Cuproptosis.

Molecular neurobiology·2026
Same journal

The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia.

Molecular neurobiology·2026
See all related articles

Acetylcholine enhances associative memory in the piriform cortex by modulating neuronal adaptation and synaptic strength. This neurotransmitter boosts learning and recall, with activity-dependent synaptic decay being key for memory capability.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cellular Neurophysiology

Background:

  • Cholinergic modulation plays a vital role in cognitive functions, including memory.
  • The piriform cortex is crucial for olfactory associative memory.
  • Understanding cellular mechanisms of neuromodulation is essential for memory research.

Purpose of the Study:

  • To investigate the role of acetylcholine in associative memory performance within the piriform cortex.
  • To elucidate the cellular and network-level effects of acetylcholine on piriform cortex function.

Main Methods:

  • Combined in vitro cellular neurophysiology in brain slices with realistic biophysical network simulations.
  • Identified and quantified the physiological effects of acetylcholine on single neurons and synaptic transmission.

Related Experiment Videos

Main Results:

  • Identified three key effects of acetylcholine: suppression of neuronal adaptation, reduced synaptic transmission in intrinsic fibers, and increased activity-dependent synaptic strength.
  • Biophysical simulations demonstrated how these effects collectively enhance learning and recall in the piriform cortex network.
  • Highlighted the critical role of activity-dependent synaptic decay in determining the network's learning capacity.

Conclusions:

  • Cholinergic signaling significantly enhances associative memory in the piriform cortex through multiple cellular mechanisms.
  • The interplay between acetylcholine's effects and activity-dependent synaptic dynamics is crucial for memory formation and retrieval.
  • Further research should explore acetylcholine's influence on long-term depression in the piriform cortex.