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[Female sterility]

K Aisaka1

  • 1Department of Obstetrics and Gynecology, Teikyo University, School of Medicine, Ichihara Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 13, 1997
PubMed
Summary

Female sterility in Japan is often caused by tubal factors, treated with IVF-ET. Ovulatory disturbances are also common, requiring endocrinological diagnosis and treatments like ovulation induction or hormonal therapies. Advanced reproductive technologies are progressing but face ethical considerations.

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Area of Science:

  • Reproductive Medicine
  • Gynecology
  • Endocrinology

Context:

  • Female sterility presents significant challenges in Japan.
  • Tubal factors, linked to endometriosis and pelvic inflammatory disease, are the leading cause.
  • Ovulatory disturbances represent the second most common factor.

Purpose:

  • To review recent advancements in diagnosing and treating female sterility in Japan.
  • To highlight the efficacy of In Vitro Fertilization-Embryo Transfer (IVF-ET) for tubal factors.
  • To discuss the management of ovulatory disturbances and other causes of infertility.

Summary:

  • Tubal factors, often resulting from endometriosis and pelvic inflammatory disease, are the primary cause of female sterility in Japan, with IVF-ET being the main treatment.
  • Ovulatory disturbances necessitate precise endocrinological evaluation, with treatments ranging from clomiphene citrate and bromocriptine to human menopausal gonadotropin-human chorionic gonadotropin (hMG-hCG) therapy, while managing risks like ovarian hyperstimulation syndrome.
  • Cervical and uterine factors are addressed through artificial insemination and IVF-ET, with limitations on surrogacy in Japan. Treatment for anti-phospholipid antibodies involves low-dose aspirin and heparin. Assisted reproductive technologies (ART), including IVF-ET, cryopreservation, and intracytoplasmic sperm injection (ICSI), are advancing but raise legal and ethical questions.

Impact:

  • Provides an overview of current female sterility treatments in Japan.
  • Emphasizes the role of assisted reproductive technologies (ART) in managing complex infertility cases.
  • Raises awareness of the ongoing legal and ethical discussions surrounding new reproductive technologies.

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