Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

J D Thompson1, T J Gibson, F Plewniak

  • 1Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS/INSERM/ULP), BP 163, 67404 Illkirch Cedex, France.

Nucleic Acids Research
|February 28, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unusual <i>5f</i> magnetism in new kagome material UV<sub>6</sub>Sn<sub>6</sub>.

npj quantum materials·2025
Same author

The impact of technical and environmental conditions on the quality assessment in mammography.

Radiography (London, England : 1995)·2024
Same author

Normal Fermi Surface in the Nodal Superconductor CeCoIn_{5} Revealed via Thermal Conductivity.

Physical review letters·2024
Same author

Absence of Spontaneous Magnetic Fields due to Time-Reversal Symmetry Breaking in Bulk Superconducting UTe_{2}.

Physical review letters·2023
Same author

Constraints on the Decay of ^{180m}Ta.

Physical review letters·2023
Same author

A scoping review of clinical practices and adherence to UK national guidance related to the placement and position confirmation of adult nasogastric feeding tubes.

Radiography (London, England : 1995)·2022

CLUSTAL X offers an improved, user-friendly interface for multiple sequence and profile alignments. This powerful tool refines alignments and identifies errors, enhancing biological sequence analysis.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Multiple sequence alignment is crucial for understanding protein and nucleic acid sequence relationships.
  • Existing tools like CLUSTAL W are widely used but may lack advanced user interface features.
  • The need for integrated, user-friendly software for sequence alignment and analysis is significant.

Purpose of the Study:

  • To introduce CLUSTAL X, a new graphical user interface for CLUSTAL W.
  • To provide an integrated system for performing, analyzing, and refining multiple sequence and profile alignments.
  • To enhance the usability and analytical capabilities for researchers in bioinformatics.

Main Methods:

  • Development of a Windows-based graphical user interface (GUI) for CLUSTAL W.

Related Experiment Videos

  • Implementation of features for sequence manipulation (cut-and-paste, reordering).
  • Inclusion of advanced alignment refinement tools, including quality analysis and selective realignment.

    • Main Results:

    • CLUSTAL X provides an intuitive interface for complex sequence alignment tasks.
    • New features enable users to easily modify, realign subsets, and analyze alignment quality.
    • The software highlights conserved regions and potential errors, aiding in the refinement of difficult alignments.

    Conclusions:

    • CLUSTAL X significantly improves the user experience for multiple sequence alignment.
    • The integrated analysis and refinement tools offer a powerful solution for improving alignment accuracy.
    • CLUSTAL X is a versatile and robust tool, available across multiple operating systems for broad accessibility.