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Glucometer analysis of one-hour glucose challenge samples

A E Dillon1, M K Menard, P Rust

  • 1Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, USA.

American Journal of Obstetrics and Gynecology
|December 16, 1997
PubMed
Summary

Point-of-care glucometer testing on venous blood offers a cost-effective diabetes screening method. This approach accurately identifies normal or abnormal glucose levels, reducing laboratory workload and costs.

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Area of Science:

  • Endocrinology
  • Clinical Chemistry
  • Point-of-care diagnostics

Background:

  • Diabetes screening in pregnancy is crucial for maternal and fetal health.
  • Traditional plasma glucose analysis can be time-consuming and costly.
  • A need exists for efficient and economical screening methods.

Purpose of the Study:

  • To evaluate a cost-saving strategy for diabetes screening using a portable glucometer on venous whole blood.
  • To establish thresholds for predicting normal or abnormal plasma glucose values after a 1-hour glucose challenge test.

Main Methods:

  • A prospective cohort study involving 222 pregnant women.
  • Venous blood was drawn 1 hour after a 50 gm glucose challenge.
  • Whole blood was analyzed using a portable glucometer, with remaining plasma sent for laboratory analysis.

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Main Results:

  • Excellent correlation (r = 0.9045) was observed between glucometer and laboratory values.
  • Selected glucometer thresholds (110 mg/dl and 155 mg/dl) accurately predicted plasma glucose levels with 95% certainty.
  • Prospective validation confirmed the complete accuracy of these thresholds.

Conclusions:

  • Venous whole blood glucometer testing reliably predicts plasma glucose values.
  • This method can immediately reassure three-fourths of patients and identify those needing further testing.
  • The model reduces automated laboratory studies by 80% and lowers overall diabetes screening costs.