Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protective serum effects in tumor immunity

J Vaage

    Israel Journal of Medical Sciences
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Tumor-specific antibodies in immune serum aided tumor rejection in mice. Passive transfer of this serum protected against intravenous tumor cell implantation, suggesting its therapeutic potential in cancer immunotherapy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis.

    Frontiers in immunology·2022
    Same author

    SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification.

    Vascular pharmacology·2019
    Same author

    Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves.

    Journal of molecular and cellular cardiology·2017
    Same author

    Mode of perfusion influences infarct size, coronary flow and stress kinases in the isolated mouse heart.

    Acta physiologica (Oxford, England)·2016
    Same author

    Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart.

    Journal of molecular and cellular cardiology·2014
    Same author

    Proteasome inhibitors eliminate protective effect of postconditioning in cultured neonatal cardiomyocytes.

    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)·2006

    Area of Science:

    • Immunology
    • Oncology
    • Cancer Research

    Background:

    • The immune system plays a crucial role in recognizing and eliminating tumor cells.
    • Tumor-induced immune suppression can hinder the host's anti-tumor response.
    • Antibody-mediated immunity is a key component of adaptive anti-tumor responses.

    Purpose of the Study:

    • To investigate the efficacy of serum containing tumor-specific antibodies in combating syngeneic tumor implants in mice.
    • To evaluate the protective effects of passive antibody transfer against different routes of tumor cell implantation.
    • To assess the potential of immune serum to reverse tumor-induced immune depression.

    Main Methods:

    • Administration of serum containing presumed tumor-specific antibodies to immunized mice with fibrosarcoma implants.

    Related Experiment Videos

  • Passive transfer of immune serum to sublethally irradiated mice with normal lymph node cells, followed by implantation of mammary carcinoma cells.
  • Treatment of mice with established mammary carcinoma and subsequent surgical cure using serum containing presumed soluble tumor antigen.

    • Main Results:

    • Immune serum administration led to the rejection of syngeneic fibrosarcoma implants in immunized mice.
    • Passive transfer of immune serum conferred protection against intravenous, but not subcutaneous, implantation of syngeneic mammary carcinoma cells.
    • Immune serum injections aided in the recovery of mice from tumor-induced specific immune depression.

    Conclusions:

    • Serum containing tumor-specific antibodies demonstrates potential in rejecting established tumors and protecting against intravenous tumor cell spread.
    • Passive antibody transfer can be effective against certain tumor implantation routes, highlighting the importance of antibody accessibility.
    • Immune serum may be a viable strategy to counteract tumor-induced immune suppression, offering a therapeutic avenue for cancer treatment.