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Related Experiment Videos

Effect of postmenopausal estrogen replacement on circulating androgens

P R Casson1, K E Elkind-Hirsch, J E Buster

  • 1Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA. pcasson@bcm.tmc.edu

Obstetrics and Gynecology
|December 16, 1997
PubMed
Summary

Estrogen replacement therapy (ERT) significantly lowers serum androgen levels, including dehydroepiandrosterone-sulfate and testosterone, in postmenopausal women. This suggests ERT may cause androgen deficiency, warranting further investigation into androgen replacement.

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Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Hormone Therapy

Background:

  • Postmenopausal women often experience hormonal changes affecting androgen levels.
  • Estrogen replacement therapy (ERT) is used to manage menopausal symptoms.
  • The impact of ERT on serum androgens in postmenopausal women requires clarification.

Purpose of the Study:

  • To investigate the effects of estrogen replacement therapy (ERT) on serum androgen levels in postmenopausal women.
  • To quantify changes in dehydroepiandrosterone (DHEA), DHEA-sulfate, and testosterone following ERT.

Main Methods:

  • A randomized, blinded, placebo-controlled crossover study.
  • 28 postmenopausal women received 2 mg/day of oral micronized estradiol for 12 weeks with a 6-week washout period.

Related Experiment Videos

  • Serum levels of androgens, estradiol, gonadotropins (LH, FSH), and sex hormone-binding globulin were measured.

    • Main Results:

    • ERT significantly increased serum estradiol (E2) levels.
    • Mean serum dehydroepiandrosterone-sulfate decreased by 23% and testosterone by 42% with ERT.
    • Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels declined, while sex hormone-binding globulin increased by 160%.

    Conclusions:

    • Menopausal ERT leads to a significant decrease in serum androgen levels (DHEA-sulfate and testosterone).
    • The reduction in testosterone may be linked to decreased LH-driven ovarian steroidogenesis.
    • ERT may induce a relative ovarian and adrenal androgen deficiency, suggesting a potential need for concurrent androgen replacement.