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Related Experiment Videos

Myodegeneration and suspected selenium/vitamin E deficiency in horses

T M Wilson, H A Morrison, N C Palmer

    Journal of the American Veterinary Medical Association
    |July 15, 1976
    PubMed
    Summary

    Nutritional myodegeneration in foals is linked to low selenium and vitamin E. Supplementation improved enzymatic activity in affected foals, supporting this diagnosis.

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    Area of Science:

    • Veterinary Pathology
    • Equine Nutrition
    • Biochemistry

    Background:

    • Myodegeneration in foals presents diagnostic challenges.
    • Nutritional deficiencies can impact equine health.
    • Selenium and Vitamin E are crucial antioxidants for muscle health.

    Purpose of the Study:

    • To investigate the clinical, macroscopic, and microscopic features of myodegeneration in foals.
    • To identify potential nutritional deficiencies associated with myodegeneration.
    • To evaluate the efficacy of selenium and vitamin E supplementation.

    Main Methods:

    • Comparative analysis of 10 foal cases.
    • Feed analysis for selenium and vitamin E content.
    • Serum selenium concentration measurements in mares.

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  • Enzyme activity assays (creatinine phosphokinase, serum glutamic oxaloacetic transaminase).
  • Histopathological examination of muscle tissues.

    • Main Results:

    • Low selenium and vitamin E levels identified in feed and low serum selenium in mares at one stable.
    • Elevated enzyme activities in affected foals.
    • Marked reduction in enzyme activities after vitamin E and selenium treatment in one foal.
    • Gross lesions included pale areas in myocardium and skeletal muscles.
    • Histological findings revealed fragmented, hyaline, and granular changes in muscle fibers.

    Conclusions:

    • Nutritional myodegeneration suspected in foals due to low selenium and vitamin E.
    • Diagnosis supported by feed analysis, serum values, enzyme activity, and treatment response.
    • Isolated cases tentatively diagnosed based on gross and microscopic findings in young animals.