Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pressure modulates monocyte migration

P C Singhal1, P Sagar, S Gupta

  • 1Department of Medicine, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park 11040, USA.

American Journal of Hypertension
|December 16, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accelerated MRI-Guided Brachytherapy in Cervical Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same author

Post-traumatic Patellar Tendon Repair with Ipsilateral Peroneus Tendon Augmentation Post Total Knee Arthroplasty: A Case Report.

Malaysian orthopaedic journal·2026
Same author

The impact of intra-abdominal pressure on urine output in postoperative cardiac surgery patients: Insights from continuous monitoring.

Journal of critical care·2025
Same author

The Surface-Topography Challenge: A Multi-Laboratory Benchmark Study to Advance the Characterization of Topography.

Tribology letters·2025
Same author

Interrelationships between social exclusion, mental health and wellbeing in adolescents: insights from a national <i>Youth Survey</i>.

Epidemiology and psychiatric sciences·2025
Same author

Amphibian Segmentation Clock Models Suggest How Large Genome and Cell Sizes Slow Developmental Rate.

Integrative organismal biology (Oxford, England)·2024
Same journal

Hemodynamic Evolution of Heart Failure from Hypertension: Lower Stroke Volume Index and Higher Heart Rate.

American journal of hypertension·2026
Same journal

Opposite Seasonal Variation in Nighttime and Morning Blood Pressure: A Longitudinal Study of Patients with Hypertension.

American journal of hypertension·2026
Same journal

Screening for Postprandial Hypotension: The Importance of Home Blood Pressure Monitoring.

American journal of hypertension·2026
Same journal

Distinct Mediating Roles of Hypertension in Arterial Stiffness Mechanisms Associated with Cardiovascular Disease Risk: A Community-Based Cohort Study.

American journal of hypertension·2026
Same journal

Long-term systolic blood pressure time in target and risk of cardiovascular events in older adults: a secondary analysis of the ASPREE cohort.

American journal of hypertension·2026
Same journal

Estimated Pulse Wave Velocity Predicts Outcomes After Acute Ischemic Stroke: A Multinational Cohort Analysis.

American journal of hypertension·2026
See all related articles

Applied pressure directly increases monocyte migration, a key factor in atherosclerosis development. Calcium channel blockers like amlodipine can reduce this migration, suggesting novel therapeutic targets beyond blood pressure reduction.

Area of Science:

  • Cardiovascular biology
  • Immunology
  • Pharmacology

Background:

  • Monocyte migration into the aorta's subendothelial space is crucial for atherosclerosis.
  • Hypertension frequently coexists with atherosclerosis, suggesting a link between pressure and disease progression.

Purpose of the Study:

  • To investigate the direct effect of applied pressure on monocyte migration.
  • To determine if amlodipine modulates monocyte migration independently of its blood pressure-lowering effects.

Main Methods:

  • Monocyte migration assays were performed under varying applied pressure conditions.
  • The effect of amlodipine, a calcium channel blocker, on monocyte migration was assessed in a dose-dependent manner.

Main Results:

Related Experiment Videos

  • Directly applied pressure significantly increased monocyte migration compared to atmospheric pressure.
  • Monocyte migration showed a direct correlation with the magnitude of applied pressure.
  • Amlodipine dose-dependently attenuated monocyte migration under both normal and elevated pressure.

Conclusions:

  • Applied pressure plays a direct role in promoting monocyte migration, contributing to atherosclerosis.
  • Vasoactive agents like amlodipine may influence monocyte migration through mechanisms independent of their effects on blood pressure.