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Primary central nervous system lymphoma: radiologic-pathologic correlation

K K Koeller1, J G Smirniotopoulos, R V Jones

  • 1Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|December 16, 1997
PubMed
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Primary central nervous system (CNS) lymphoma, once rare, is now more common. Advances in immunohistochemical stains reveal it

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Primary central nervous system (CNS) lymphoma is an increasingly recognized neoplasm.
  • Immunohistochemical stains have significantly advanced understanding of this B-cell malignancy.
  • The exact etiology of primary CNS lymphoma remains under investigation.

Purpose of the Study:

  • To provide an overview of primary CNS lymphoma.
  • To discuss its pathological features and diagnostic characteristics.
  • To review current understanding of its prognosis and treatment.

Main Methods:

  • Review of existing literature on primary CNS lymphoma.
  • Analysis of immunohistochemical and imaging findings.
  • Discussion of clinical presentation and outcomes.

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Main Results:

  • Primary CNS lymphomas are predominantly B-cell neoplasms.
  • Characteristic perivascular spread and periventricular predilection are noted.
  • Typical imaging findings include hyperattenuation on CT and hypointensity on T2-weighted MRI, with contrast enhancement.

Conclusions:

  • Despite poor prognosis, advances in radiation and chemotherapy offer improved outcomes.
  • Further research into the cause of primary CNS lymphoma is warranted.
  • Multidisciplinary approaches are crucial for managing this rare tumor.