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Flurazepam toxicosis in two dogs
1College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA.
Veterinary and Human Toxicology
|December 16, 1997
Summary
Two dogs died after malicious poisoning with flurazepam, a benzodiazepine hypnotic. Flurazepam was detected in one dog
Area of Science:
- Veterinary Toxicology
- Pharmacology
Background:
- Flurazepam is a benzodiazepine (BZD) derivative and a controlled substance.
- It is commonly prescribed for sleep disorders.
Observation:
- Two dogs experienced fatal outcomes due to malicious poisoning with flurazepam.
- Flurazepam was identified in the urine of one affected dog using thin-layer chromatography.
Findings:
- Benzodiazepine poisoning can be fatal in companion animals.
- Analytical methods can detect flurazepam in animal urine.
Implications:
- Flumazenil, a BZD receptor antagonist used in humans, may be a potential treatment for benzodiazepine intoxication in companion animals.
- This case highlights the risks of illicit drug administration to animals and the need for effective antidotes.