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Oral treatment options for onychomycosis
1Pennsylvania College of Podiatric Medicine, Philadelphia 19107, USA.
Journal of the American Podiatric Medical Association
|December 16, 1997
Summary
New oral antifungal medications offer a potentially curative treatment for onychomycosis (fungal nail infections). This review covers itraconazole, terbinafine, and fluconazole, marking a shift from palliative care to effective antifungal therapy.
Area of Science:
- Podiatry
- Dermatology
- Pharmacology
Background:
- Onychomycosis (fungal nail infection) has traditionally been managed with palliative treatments.
- Oral antifungal agents have emerged as a significant advancement in treating fungal nail infections.
Purpose of the Study:
- To review new oral antifungal agents for onychomycosis treatment.
- To compare itraconazole, terbinafine, and fluconazole regarding their history, efficacy, dosing, safety, and cost.
Main Methods:
- Literature review of oral antifungal agents for onychomycosis.
- Analysis of efficacy, safety, dosing, and cost data for key antifungal drugs.
Main Results:
- It discusses the history, mechanisms of action, efficacies, dosing, safety profiles, and costs of itraconazole, terbinafine, and fluconazole.
- These agents represent a paradigm shift in treatment approaches.
Conclusions:
- New oral antifungals provide a potentially curative treatment for onychomycosis.
- Podiatric physicians can now offer effective antifungal therapy instead of solely palliative nail debridement.