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Physiologically based pharmacokinetic models for anticancer drugs

H S Chen, J F Gross

    Cancer Chemotherapy and Pharmacology
    |January 1, 1979
    PubMed
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    Physiologically based pharmacokinetic (PBPK) models are crucial for anticancer drug development. Future research will optimize cancer chemotherapy by refining PBPK models for individual patient treatment.

    Area of Science:

    • Pharmacology
    • Pharmacokinetics
    • Computational Biology

    Background:

    • Physiologically based pharmacokinetic (PBPK) models offer a mechanistic approach to understanding drug behavior.
    • The development and application of PBPK models, particularly for anticancer drugs, have a significant history.
    • These models integrate physiological and biochemical data to predict drug disposition.

    Purpose of the Study:

    • To review the rationale and history of PBPK model development.
    • To discuss methods for constructing PBPK models and their prior use in anticancer drug studies.
    • To identify key areas for future research in PBPK modeling for oncology.

    Main Methods:

    • Literature review of PBPK model development and applications.
    • Discussion of PBPK model construction methodologies.

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  • Analysis of existing PBPK models applied to anticancer agents.

    • Main Results:

    • The historical development and rationale behind PBPK models are presented.
    • Methods for constructing PBPK models are outlined.
    • Previous applications of PBPK models in anticancer drug research are discussed.

    Conclusions:

    • Future research should prioritize interspecies scaling for PBPK models.
    • Investigating the impact of disease states on anticancer drug pharmacokinetics is essential.
    • Applying PBPK modeling to cancer cell growth studies will advance the field.
    • The ultimate aim is to personalize cancer chemotherapy regimens for improved patient outcomes.