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Treatment of methanol poisoning with intravenous 4-methylpyrazole
M J Burns1, A Graudins, C K Aaron
1Department of Emergency Medicine, University of Massachusetts Medical Center, Worcester, USA. mburns@bidmc.harvard.edu
Annals of Emergency Medicine
|December 17, 1997
Abstract:
Treatment of human methanol poisoning with the alcohol dehydrogenase inhibitor, 4-methylpyrazole (fomepizole), has not been previously described. We report the clinical and toxicokinetic data of a patient with methanol poisoning who was treated with fomepizole. Formic acid levels remained undetectable during fomepizole treatment, the toxic effects of methanol were prevented, and the patient made a full recovery.