Blood compatible phospholipid-containing polyurethanes: synthesis characterization and blood compatibility evaluation

Area of Science:

• Polymer Chemistry
• Biomaterials Science
• Surface Chemistry

Background:

• Phospholipid-based materials offer unique properties for biomedical applications.
• Poly(ether urethane)s are widely used biomaterials but can elicit adverse biological responses.
• Developing novel polyurethanes with enhanced biocompatibility is crucial for medical device innovation.

Purpose of the Study:

• To synthesize and characterize a novel diol containing phosphatidylcholine analogous moieties.
• To incorporate this diol into poly(ether urethane)s using varying poly(ethylene oxide) molecular weights.
• To evaluate the bulk, surface, and blood compatibility characteristics of the resulting phospholipid poly(ether urethane)s.

Main Methods:

• Synthesis and characterization of bis[2-(2-hydroxyethyldimethylammonio)ethyl] butylenediphosphate diol.
• Polymerization of the diol with poly(ethylene oxide) and 4,4'-methylenediphenyl diisocyanate.
• Analysis using IR, GPC, ATR-FTIR, ESCA, and contact angle measurements.
• Blood compatibility assessment via platelet rich plasma contacting studies and SEM.

Main Results:

• The novel phospholipid poly(ether urethane)s exhibited polyelectrolyte viscosity behavior.
• Surface analysis revealed relatively hydrophilic characteristics.
• Crucially, no platelet adhesion was observed on the casting films, indicating excellent hemocompatibility.

Conclusions:

• A new class of phospholipid poly(ether urethane)s was successfully synthesized.
• These polymers possess favorable hydrophilic surfaces and superior blood compatibility.
• The demonstrated hemocompatibility suggests significant potential for these novel materials in diverse biomedical applications.