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Long-acting diltiazem CD is safe and effective in a hypertensive Mexican-American population
C R Herrera1, A Lewin, R Fiddes
1Department of Internal Medicine, University of Texas-Houston, 77030, USA.
Study Objective:
To evaluate the safety and effectiveness of diltiazem CD for reducing blood pressure in Mexican-American patients with mild to moderate hypertension.
Design:
Randomized, double-blind, placebo-controlled trial.
Setting:
Twelve clinical sites in the United States.
Patients:
Patients with baseline diastolic blood pressures between 95 and 115 mm Hg.
Interventions:
Patients were treated with an average daily dose of diltiazem CD 246 mg (60 patients) or placebo (58 patients) to achieve a trough diastolic blood pressure below 90 mm Hg.
Measurements And Main Results:
Diltiazem CD significantly reduced mean diastolic blood pressure compared with placebo, -8.2 versus -4.1 mm Hg, respectively (p=0.0025). Diastolic blood pressure below 90 mm Hg or a reduction of 10 mm Hg or more was achieved by 57% of diltiazem CD versus 28% of placebo recipients. Systolic blood pressure and heart rate were also reduced with diltiazem CD. Adverse events were mild, with similar frequency for diltiazem CD (15%) and placebo (19%).
Conclusion:
Diltiazem CD is safe and effective in hypertensive Mexican-Americans, and diastolic blood pressure reductions compare with those in non-Hispanic white patients.