Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Genome Sequence DataBase (GSDB): improving data quality and data access

C Harger1, M Skupski, J Bingham

  • 1National Center for Genome Resources, 1800 Old Pecos Trail, Suite A, Santa Fe, NM 87505, USA. cah@ncgr.org

Nucleic Acids Research
|February 21, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A participatory photovoice investigation of community assets, barriers, and opportunities to curb the opioid epidemic.

Journal of substance use and addiction treatment·2025
Same author

Correction to: Digital messaging to support control for type 2 diabetes (StAR2D): a multicentre randomised controlled trial.

BMC public health·2022
Same author

Investigations of proximity-induced superconductivity in the topological insulator Bi<sub>2</sub>Te<sub>3</sub> by microRaman spectroscopy.

Scientific reports·2021
Same author

Digital messaging to support control for type 2 diabetes (StAR2D): a multicentre randomised controlled trial.

BMC public health·2021
Same author

Process evaluation of a brief messaging intervention to improve diabetes treatment adherence in sub-Saharan Africa.

BMC public health·2021
Same author

Feasibility, user experiences, and preliminary effect of <i>Conversation Cards for Adolescents©</i> on collaborative goal-setting and behavior change: protocol for a pilot randomized controlled trial.

Pilot and feasibility studies·2020
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles
This summary is machine-generated.

The Genome Sequence DataBase (GSDB) enhanced data quality by removing vector contamination and improved accessibility through new tools like a sequence viewer and query updates. These efforts aim to support genomic and gene-level studies.

Area of Science:

  • Bioinformatics
  • Genomics
  • Database Management

Background:

  • The Genome Sequence DataBase (GSDB) at the National Center for Genome Resources aimed to enhance its utility for researchers.
  • Improving data quality and accessibility were key objectives for GSDB in 1997.

Purpose of the Study:

  • To improve the quality of genomic sequence data within the GSDB.
  • To increase the accessibility of GSDB data for various research applications.
  • To support genomic comparison and gene-level studies through enhanced data resources.

Main Methods:

  • Implemented projects to identify and remove vector contamination from sequences.
  • Developed premier sequence sets, including alignments and discontiguous sequences.
  • Introduced a graphical database sequence viewer and updated the Maestro web-based query tool.

Related Experiment Videos

  • Developed the Excerpt tool for retrieving specific sequence regions and a GSDB flatfile with unique annotations.
  • Integrated a tool for detecting matrix attachment regions (MARs) on the GSDB website.

    • Main Results:

    • Vector contamination was identified and removed, improving sequence data integrity.
    • New tools, including a graphical viewer and Excerpt, were released to facilitate data access.
    • Enhanced annotation capabilities and the MAR detection tool were made available.
    • The GSDB became a more robust resource for genomic and gene-level research.

    Conclusions:

    • The enhancements to GSDB in 1997 significantly improved data quality and accessibility.
    • These improvements position GSDB as a more valuable resource for genomic comparison and gene-level studies.
    • The development of specialized tools and data sets addresses the evolving needs of the research community.