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IXDB, an X chromosome integrated database

U Leser1, R Wagner, A Grigoriev

  • 1Max-Planck-Institut für Molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany.

Nucleic Acids Research
|February 21, 1998
PubMed
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The integrated X chromosome database (IXDB) provides a centralized repository for human X chromosome physical mapping data. It facilitates the creation of comprehensive integrated maps by connecting diverse data sources and experimental results.

Area of Science:

  • Genomics
  • Bioinformatics
  • Human Genetics

Background:

  • Physical mapping data for the human X chromosome is fragmented across numerous sources.
  • A unified resource is needed to consolidate and integrate this dispersed information.

Purpose of the Study:

  • To introduce the integrated X chromosome database (IXDB) as a comprehensive repository for human X chromosome physical mapping data.
  • To detail the features and goals of IXDB in supporting integrated map construction.

Main Methods:

  • Data integration from multiple sources with a focus on experimental connections.
  • Development of a flexible and extensible database schema.
  • Implementation of a user-friendly WWW interface and a JAVA-based graphical map viewer.

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Main Results:

  • IXDB successfully integrates diverse physical mapping data for the human X chromosome.
  • The database features a flexible schema, a cross-referenced WWW interface, and a graphical map viewer.
  • Emphasis is placed on recording experimental data linking mapping objects.

Conclusions:

  • IXDB serves as a valuable resource for consolidating human X chromosome physical mapping information.
  • The database architecture and features are designed to support the construction of integrated physical, genetic, transcript, and sequence maps.
  • IXDB aims to significantly advance the comprehensive mapping of the human X chromosome.